Michael C. Kelly

The paper uses single-cell RNA sequencing to show heterogeneous SLFN11 expression in cancer cells, linking it to stress response and genome maintenance.

This study shows that deep vein thrombosis primes neutrophils to promote brain metastasis in triple-negative breast cancer by enhancing their recruitment and NET formation.

The paper uses long-read sequencing to analyze genomic and epigenomic changes in melanoma subclones, revealing parallel evolutionary paths and lineage-specific methylation patterns.

This study shows that inhibiting MAPK signaling suppresses CMV reactivation in CD34+ Kasumi-3 cells, suggesting a therapeutic target for preventing viral reactivation in immunocompromised patients.

Visium profiling of nine pediatric osteosarcoma pulmonary metastases reveals a conserved granuloma-like architecture: inflamed macrophage-rich periphery, collagen capsule, inflammation-poor core, and CXCR4 as candidate target.

The paper estimates and corrects index hopping misassignments in scRNA-seq data by analyzing signature genes across cell types and adjusting expression levels.

The paper identifies a conserved excitatory neuron gradient in human mediodorsal thalamus using single-nucleus and spatial transcriptomics, linking it to psychiatric disorder risk.

gEAR provides a community-driven portal for multi-omic data visualization, analysis, and sharing across species and data types.

Trisicell infers subclonal expansion patterns and therapeutic impact of intratumor heterogeneity from scRNAseq data, revealing correlations between mutational composition and tumor aggressiveness.

This study investigates BRCA2's role in protecting DNA at interstrand crosslinks and shows its distinct function compared to its role in hydroxyurea-induced fork protection.