A non-autonomous protein quality control mechanism targeting tau aggregate propagation
Anika Bluemke, Birte Hagemeier, Kamilla Ripkens, Nina Schulze, Michal Strzala, Michelle Koci, Farnusch Kaschani, Markus Kaiser, Michael Erkelenz, Sebastian Schluecker, Melisa Merdanovic, Simon Poepsel, Doris Hellerschmied, Steven G. Burston, Michael Ehrmann
This study identifies HTRA1 as a non-autonomous protein quality control factor that inhibits tau aggregate propagation by interfering with multiple steps of the spreading process.
bioRxiv · Jul 26, 2024 · PreprintBiochemistry