Claudin-5 binder enhances focused ultrasound-mediated opening in an in vitro blood-brain barrier model
Liyu Chen, Ratneswary Sutharsan, Jonathan LF Lee, Esteban Cruz, Blaise Asnicar, Tishila Palliyaguru, Joanna Marta Wasielewska, Arnaud Gaudin, Jae Hee Song, Gerhard Leinenga, Jürgen Götz
The paper demonstrates that pre-incubating BBB models with claudin-5 binders enhances FUS-mediated BBB opening, allowing lower acoustic pressures and improved permeability.
Theranostics · Jan 1, 2022Peer-reviewedNeuroscience