Author

Liyu Chen

The University of QueenslandORCID 0000-0001-6552-8015Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:drug response / drug discovery· 1 Organism:human· 1

Frequent Co-Authors

Gerhard LeinengaiD· 2 shared Jae Hee SongiD· 2 shared Joanna Marta WasielewskaiD· 2 shared Jürgen GötziD· 2 shared Alice PébayiD· 1 shared Anthony Robert WhiteiD· 1 shared Arnaud GaudiniD· 1 shared Blaise Asnicar· 1 shared

Activity by Year

2022-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersNeuroscience

Gerhard LeinengaORCID

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2 papers

Recent·Most cited

A sporadic Alzheimer's blood-brain barrier model for developing ultrasound-mediated delivery of Aducanumab and anti-Tau antibodies.

Joanna Marta Wasielewska, Juliana C.S. Chaves, Rebecca L. Johnston, Laura A. Milton, Damián Hernández, Liyu Chen, Jae Hee Song, Wendy Lee, Gerhard Leinenga, Rebecca M. Nisbet, Alice Pébay, Jürgen Götz, Anthony Robert White, Lotta E. Oikari

This study demonstrates that focused ultrasound with microbubbles enhances the delivery of Aducanumab and anti-Tau antibodies across a human sporadic Alzheimer's disease blood-brain barrier model.

Theranostics · Jan 1, 2022Peer-reviewedNeuroscience

Claudin-5 binder enhances focused ultrasound-mediated opening in an in vitro blood-brain barrier model

Liyu Chen, Ratneswary Sutharsan, Jonathan LF Lee, Esteban Cruz, Blaise Asnicar, Tishila Palliyaguru, Joanna Marta Wasielewska, Arnaud Gaudin, Jae Hee Song, Gerhard Leinenga, Jürgen Götz

The paper demonstrates that pre-incubating BBB models with claudin-5 binders enhances FUS-mediated BBB opening, allowing lower acoustic pressures and improved permeability.

Theranostics · Jan 1, 2022Peer-reviewedNeuroscience