Jae Hee Song

This study uses high-resolution imaging to compare the spatiotemporal biological responses of reversibly and irreversibly sonoporated cells, revealing distinct cellular bioeffects that determine their long-term fates.

The paper analyzes the transcriptomic response of microglia in an Alzheimer's disease mouse model treated with scanning ultrasound, identifying differentially expressed genes and pathways related to phagocytosis and cell cycle activation.

This study demonstrates that focused ultrasound with microbubbles enhances the delivery of Aducanumab and anti-Tau antibodies across a human sporadic Alzheimer's disease blood-brain barrier model.

The paper demonstrates that pre-incubating BBB models with claudin-5 binders enhances FUS-mediated BBB opening, allowing lower acoustic pressures and improved permeability.