Gerhard Leinenga

Scanning ultrasound-mediated memory and functional improvements do not require amyloid-β reduction

The paper shows that ultrasound treatment improves memory in AD mice without reducing amyloid-β, with higher frequency (1 MHz) being more effective than lower frequencies.

Transcriptional signature in microglia isolated from an Alzheimers disease mouse model treated with scanning ultrasound

The paper analyzes the transcriptomic response of microglia in an Alzheimer's disease mouse model treated with scanning ultrasound, identifying differentially expressed genes and pathways related to phagocytosis and cell cycle activation.

A sporadic Alzheimer's blood-brain barrier model for developing ultrasound-mediated delivery of Aducanumab and anti-Tau antibodies.

This study demonstrates that focused ultrasound with microbubbles enhances the delivery of Aducanumab and anti-Tau antibodies across a human sporadic Alzheimer's disease blood-brain barrier model.

Claudin-5 binder enhances focused ultrasound-mediated opening in an in vitro blood-brain barrier model

The paper demonstrates that pre-incubating BBB models with claudin-5 binders enhances FUS-mediated BBB opening, allowing lower acoustic pressures and improved permeability.

A comparative study of the effects of Aducanumab and scanning ultrasound on amyloid plaques and behavior in the APP23 mouse model of Alzheimer disease

This study compares the effects of Aducanumab and scanning ultrasound on amyloid plaques and behavior in APP23 mice, finding that both reduce plaques and that the combination improves spatial memory.