A Step-wise, Deterministic and Fatal Mouse Model of Myeloid Neoplasm with Spontaneous Acquisition of Patient-relevant RTK-RAS Mutations
Marija Zarocsinceva, M. Saeed Qureshi, Nicola K. Wilson, George Giotopoulos, Blaise Musabe, Katherine Sturgess, M. S. Vijayabaskar, Sarah Kinston, Ryan J. Asby, David J. Adams, Brian J.P. Huntly, Fernando J. Calero‐Nieto, Berthold Göttgens
This study creates a mouse model of myeloid neoplasm with spontaneous RTK-RAS mutations, showing a premalignant phase and lineage restriction in tumors.
Oncogene · Sep 4, 2026Peer-reviewedCancer Biology