M. S. Vijayabaskar

A scalable in vitro cell competition model identifies preleukemic super competitor clones

This study develops an in vitro clonal competition model to identify preleukemic TET2-mutant clones that suppress wild-type cells through RAC1-GEF signalling inhibition.

A Step-wise, Deterministic and Fatal Mouse Model of Myeloid Neoplasm with Spontaneous Acquisition of Patient-relevant RTK-RAS Mutations

This study creates a mouse model of myeloid neoplasm with spontaneous RTK-RAS mutations, showing a premalignant phase and lineage restriction in tumors.

Multi-scale modeling of human tissues from spatial transcriptomics with TERRA

TERRA is a foundation model for spatial transcriptomics that predicts tissue behavior under perturbation and identifies multi-scale biological insights across tissues.

An integrated single cell and spatial omics atlas of human prenatal development

Human Developmental Cell Atlas integrates ~4.6 million cells/nuclei from 4-22 post-conception weeks into 454 refined cell types and maps 114 spatial niches across 6PCW whole-embryo sections.

Self-supervised learning for a gene program-centric view of cell states

Tripso, a self-supervised transformer model, identifies gene program-specific embeddings and discovers novel gene programs, revealing biological insights in hematopoietic development and disease.

Predicting how perturbations reshape cellular trajectories with PerturbGen

PerturbGen predicts how genetic perturbations affect cellular trajectories across time in human datasets, showing effects on immune responses, hematopoiesis, and skin development.

Selection of pre-leukemic hematopoietic stem cells driven by distinct extracellular matrix molecules

The paper characterizes Tet2-mutant HSCs using multi-omic data and identifies ECM molecules as regulators of self-renewal in pre-leukemic HSCs.

Multi-organ functions of yolk sac during human early development

The paper maps the multi-organ functions of the human yolk sac during early development, revealing its roles in hematopoiesis, nutrition, and oxygen regulation.