Large oncosomes reprogram bone marrow mesenchymal stem cells to establish a pre-metastatic niche
Taylon Felipe Silva, Virgínia Márcia Concato, Fatima Bedier, Lauren Newman, Diána Kitka, Jamelle Brown, Blandine Victor, Minhyung Kim, Tatyana Vagner, Catherine S. Grasso, Dmitriy Sheyn, Sungyong You, Michael R. Freeman, Fayyaz Shiraz Sutterwala, Helen S. Goodridge, , Dolores Di Vizio
This study shows that large oncosomes reprogram bone marrow mesenchymal stem cells to create a pre-metastatic niche by inducing an interferon-driven inflammatory response.
Advanced Science · Oct 25, 2026Peer-reviewedCancer Biology