MAP4K inhibition by the CNS penetrant inhibitor famlasertib restrains medulloblastoma dissemination without developmental toxicity
Marc Thomas Schönholzer, Meng-Syuan Lin, Shen Yan, Veronica Akle Alvarez, Amin Allalou, Bernard Ciraulo, Dejana Versamento, Levi Luca Kopp, Dina Hochuli, Bleiker Tanja, Welti Annik, Stephan C. F. Neuhauss, Martin Baumgartner
This study shows that famlasertib, a MAP4K inhibitor, reduces medulloblastoma cell invasion in vitro and in zebrafish models without causing developmental toxicity.
bioRxiv · Jul 23, 2026 · PreprintCancer Biology