Meng-Syuan Lin

This study shows that famlasertib, a MAP4K inhibitor, reduces medulloblastoma cell invasion in vitro and in zebrafish models without causing developmental toxicity.

This study maps the FRS2 interactome in medulloblastoma cells, identifying novel proteins involved in cell migration and invasion, and highlights FRS2's role in tumor aggressiveness.

PHIROS enables long-term, high-resolution imaging of organotypic brain slices with controlled perfusion, revealing dynamic tumor-astrocyte interactions and mitochondrial transfer.

This study shows that reduced CLSTN1 expression, regulated by MAP4 kinase, increases invasiveness in medulloblastoma by affecting cell-cell interactions and growth factor responses.