Bob Strome

Computational design of intrinsically disordered protein regions by matching bulk molecular properties

The paper designs synthetic intrinsically disordered regions by minimizing molecular property distances to known IDRs, showing expected patterns in cells.

Proteome-wide signatures of function in highly diverged intrinsically disordered regions

The paper identifies evolutionary signatures in intrinsically disordered regions that correlate with functional annotations and phenotypes.

Short linear motifs in intrinsically disordered regions modulate HOG signaling capacity

The paper identifies functional short linear motifs in disordered regions of HOG signaling proteins and shows their quantitative impact on pathway output through experimental and computational approaches.

An analog to digital converter creates nuclear localization pulses in yeast calcium signaling

The paper shows that constant calcium stress causes stochastic nuclear localization pulses of Crz1 in yeast, proposing a model where time delays and stochasticity convert analog calcium signals into digital pulses.