Taraneh Zarin

The paper maps the functional landscape of the human intrinsically disordered proteome using evolutionary signatures to classify and predict IDR functions.

This study quantifies how domain extensions in a PDZ protein reshape its energy and allosteric landscapes through extensive mutational analysis.

The paper maps how specificity in protein-ligand interactions is encoded and shows how mutations can reprogram binding specificity across multiple sites.

The paper introduces a method to discover molecular features of intrinsically disordered regions using contrastive learning with evolutionary conservation.

The paper identifies evolutionary signatures in intrinsically disordered regions that correlate with functional annotations and phenotypes.

The paper identifies functional short linear motifs in disordered regions of HOG signaling proteins and shows their quantitative impact on pathway output through experimental and computational approaches.