Author

Sergey V. Plotnikov

University of TorontoORCID 0000-0002-5561-8890Unclaimed ORCID profile · follow to get notified of new preprints

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Sergey V. Plotnikov1 paper

Biology Disciplines

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Cell Biology· 2 Systems Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Assay:imaging· 1 Approach:mechanistic / dynamical model· 1 Approach:statistical model· 1 Organism:yeast· 1

Frequent Co-Authors

Alan M MosesiD· 1 shared Alexander Bogatch· 1 shared Bob Strome· 1 shared Changsong Yang· 1 shared Chengyin LiiD· 1 shared Christopher A. McCullochiD· 1 shared Ernest IuiD· 1 shared Fernando R. ValenciaiD· 1 shared

Activity by Year

2018-2026 · peak 1/yr

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10 top collaborators · 24 mutual co-author links

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1 shared paperSystems Biology

Alan M MosesORCID

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3 papers

Recent·Most cited

Cell BiologyCurrent BiologyPeer-reviewedFeb 1, 2026

A TRPV4-dependent calcium signaling axis governs lamellipodial actin architecture to promote cell migration

Ernest Iu, Alexander Bogatch, Wenjun Deng…·Sergey V. Plotnikov

The paper identifies a TRPV4-dependent Ca2+ signaling pathway that regulates lamellipodia actin architecture and promotes cell migration through RhoA and formin-mediated actin assembly.

DOI 10.1016/j.cub.2026.01.024

imagingexperimental assay

𝕏 PostBluesky

Cell BiologybioRxivPreprintNov 12, 2025

A tale of two distinct actin networks underlies the entire life cycle of focal adhesion

Rico Dong, Karan Ishii, Sergey V. Plotnikov, Jian Liu

This study reveals how focal adhesions are dynamically regulated by retrograde actin flow and stress fibers during cell migration.

DOI 10.1101/2025.11.12.688129

experimental assaymechanistic / dynamical model

𝕏 PostBluesky

Systems BiologybioRxivPreprintJun 28, 2018

An analog to digital converter creates nuclear localization pulses in yeast calcium signaling

Ian Shen Hsu, Bob Strome, Sergey V. Plotnikov, Alan M Moses

The paper shows that constant calcium stress causes stochastic nuclear localization pulses of Crz1 in yeast, proposing a model where time delays and stochasticity convert analog calcium signals into digital pulses.

DOI 10.1101/357939

yeaststatistical model

𝕏 PostBluesky