Iva Pritišanac

A histidine switch controls the pH-responsive self-assembly of a helical protein filament

The paper identifies a histidine switch that regulates pH-responsive self-assembly of a helical protein filament through electrostatic interactions.

A Functional Map of the Human Intrinsically Disordered Proteome

The paper maps the functional landscape of the human intrinsically disordered proteome using evolutionary signatures to classify and predict IDR functions.

Proteome-wide identification and modeling of interactions between transactivation domains and arginine-glycine-rich regions

The paper identifies and models interactions between transactivation domains and arginine-glycine-rich regions using proteome-scale data and simulations, revealing electrostatic mechanisms driving TF-RBP coupling.

The sequence context of RG/RGG motifs determines condensate formation, transportin-1 binding and chaperoning

The paper investigates how sequence context of RG/RGG motifs influences condensate formation, transportin-1 binding, and chaperoning using bioinformatics and experimental analysis.

A histidine switch regulates pH-dependent filament formation by the caspase-9 CARD

This study identifies a histidine switch in C9CARD that regulates pH-dependent filament formation through electrostatic interactions and structural changes.

TSC22D, WNK and NRBP gene families exhibit functional buffering and evolved with Metazoa for macromolecular crowd sensing

This study identifies functional relationships between TSC22D, WNK, and NRBP gene families in macromolecular crowding sensing and cell volume regulation across metazoans.

Flattening the curve - How to get better results with small deep-mutational-scanning datasets

This paper improves prediction performance on small DMS datasets by using structural representations and data augmentation, achieving results comparable to sequence-based methods on large datasets.

Glutamate as a co-agonist for acid-sensing ion channels to aggravate ischemic brain damage

This study identifies glutamate as a co-agonist for acid-sensing ion channels (ASICs) that worsens ischemic brain damage, and presents a small molecule inhibitor that targets this interaction without affecting NMDARs.

Computational design of intrinsically disordered protein regions by matching bulk molecular properties

The paper designs synthetic intrinsically disordered regions by minimizing molecular property distances to known IDRs, showing expected patterns in cells.

Developmental Dynamics of RNA Translation in the Human Brain

This study maps RNA translation dynamics in the human brain using ribosome profiling, identifying thousands of novel translation events and brain-specific microproteins linked to schizophrenia.

Discovering molecular features of intrinsically disordered regions by using evolution for contrastive learning

The paper introduces a method to discover molecular features of intrinsically disordered regions using contrastive learning with evolutionary conservation.

A recurrent SHANK3 frameshift variant in Autism Spectrum Disorder

The paper identifies a recurrent SHANK3 frameshift variant in Autism Spectrum Disorder, showing de novo mutations and variable expressivity.