Whole-body Bacteriophage Distribution Characterized by a Physiologically based Pharmacokinetic Model
Arne Echterhof, Tejas Dharmaraj, Patrick M. Blankenberg, Bobby Targ, Paul L. Bollyky, Nicholas M. Smith, Francis G. Blankenberg
This paper develops a physiologically based pharmacokinetic model to characterize the whole-body distribution of bacteriophages in mice, finding rapid elimination and the need for multi-dose regimens.
bioRxiv · Feb 6, 2025 · PreprintMicrobiology