A Universal, Single-Component Multilayered Self-Assembling Protein Nanoparticle Vaccine Based on Extracellular Domains of Matrix Protein 2 Against Both Influenza A and B
Yi-Nan Zhang, Keegan Braz Gomes, Yi-Zong Lee, Garrett Ward, Bomin Xie, Sarah Auclair, Linling He, Jiang Zhu
This paper develops a single-component self-assembling nanoparticle vaccine targeting conserved M2e domains from both influenza A and B viruses, showing 100% protection against H1N1 and 70% against Yamagata lineage influenza B in mice.
Vaccines · Aug 28, 2024Peer-reviewedMicrobiology