Yi-Zong Lee

This paper designs de novo minibinders that inhibit blood-stage malaria replication with nanomolar potency by targeting the RH5-basigin interaction.

This study designs stabilized HA trimers on self-assembling protein nanoparticles to improve influenza vaccine efficacy by enhancing immunogenicity and lymph node retention.

This study identifies the conserved bridging domain on HCV E1E2 as a target for neutralizing antibodies from diverse lineages, showing additivity with neutralizing face antibodies.

The paper designs, characterizes, and tests a soluble HCV E1E2 heterodimer and self-assembling nanoparticles for vaccine development.

This study rationally designs and characterizes filovirus glycoproteins and nanoparticles in vitro and in vivo to aid vaccine development.

The study analyzes metastability in fusion proteins of RSV and hMPV to design stable uncleaved prefusion-closed trimers for vaccine development.

This paper develops a single-component self-assembling nanoparticle vaccine targeting conserved M2e domains from both influenza A and B viruses, showing 100% protection against H1N1 and 70% against Yamagata lineage influenza B in mice.