Keegan Braz Gomes

This study designs stabilized HA trimers on self-assembling protein nanoparticles to improve influenza vaccine efficacy by enhancing immunogenicity and lymph node retention.

This study rationally designs and characterizes filovirus glycoproteins and nanoparticles in vitro and in vivo to aid vaccine development.

The study analyzes metastability in fusion proteins of RSV and hMPV to design stable uncleaved prefusion-closed trimers for vaccine development.

This paper develops a single-component self-assembling nanoparticle vaccine targeting conserved M2e domains from both influenza A and B viruses, showing 100% protection against H1N1 and 70% against Yamagata lineage influenza B in mice.