Author

Sarah Auclair

Scripps Research InstituteORCID 0000-0002-4701-1087Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:mouse· 2 Assay:proteomics· 1 Assay:structural biology· 1

Frequent Co-Authors

Garrett Ward· 2 shared Jiang ZhuiD· 2 shared Keegan Braz GomesiD· 2 shared Linling HeiD· 2 shared Yi-Nan ZhangiD· 2 shared Yi-Zong LeeiD· 2 shared Andrew B. WardiD· 1 shared Bomin Xie· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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2 shared papersMicrobiology

Garrett Ward

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2 papers

Recent·Most cited

Rational design of next-generation filovirus vaccines through glycoprotein stabilization, nanoparticle display, and glycan modification

Yi-Zong Lee, Yi-Nan Zhang, Maddy L. Newby, Garrett Ward, Keegan Braz Gomes, Sarah Auclair, Connor DesRoberts, Joel D. Allen, Andrew B. Ward, Robyn L. Stanfield, Linling He, Max Crispin, Ian A. Wilson, Jiang Zhu

This study rationally designs and characterizes filovirus glycoproteins and nanoparticles in vitro and in vivo to aid vaccine development.

bioRxiv · Mar 2, 2025 · PreprintMicrobiology

A Universal, Single-Component Multilayered Self-Assembling Protein Nanoparticle Vaccine Based on Extracellular Domains of Matrix Protein 2 Against Both Influenza A and B

Yi-Nan Zhang, Keegan Braz Gomes, Yi-Zong Lee, Garrett Ward, Bomin Xie, Sarah Auclair, Linling He, Jiang Zhu

This paper develops a single-component self-assembling nanoparticle vaccine targeting conserved M2e domains from both influenza A and B viruses, showing 100% protection against H1N1 and 70% against Yamagata lineage influenza B in mice.

Vaccines · Aug 28, 2024Peer-reviewedMicrobiology