Bone regulates locomotion by sustaining motoneuronal mitochondrial function
David Romeo-Guitart, Tala Tirani, Dimitrije Milunov, Angie K. Torres-Juacida, Boris Lamotte, Carolina Arenas-Plascencia, Sylvère Durand, Ivan Nemazanyy, Stéphanie Moriceau, Soham Saha, Gérard Karsenty, Franck Oury
This study shows that bone-derived hormone osteocalcin regulates locomotion by maintaining mitochondrial function in spinal motoneurons, and that this effect can be reversed in aged mice.
bioRxiv · Oct 8, 2026 · PreprintNeuroscience