Sylvère Durand

This study shows that bone-derived hormone osteocalcin regulates locomotion by maintaining mitochondrial function in spinal motoneurons, and that this effect can be reversed in aged mice.

The paper identifies a plasma protein signature that predicts cancer in patients with cardiovascular disease, using data from two cohorts.

This study identifies a metabolic vulnerability in osteosarcoma by combining AIF/CHCHD4 inhibition and GLS1 suppression, showing synergy between mitoxantrone and telaglenastat in vitro and in vivo.

This study identifies taurine as a host metabolite that inhibits malaria parasite cytoadhesion in asymptomatic infections, suggesting its potential as a therapeutic target.

This study shows that spermidine supplementation improves depression symptoms by enhancing autophagy and correcting polyamine imbalances in both humans and mice.

The paper introduces a two-phase model of ageing using Smurfness to distinguish chronological age effects from biological age effects in transcriptional data.