Soham Saha

This study shows that mitochondrial dysfunction contributes to premature musculoskeletal aging in HCH mice, with proteomics revealing altered aging trajectories and bone fragility.

This study identifies PTH1R signaling in AgRP neurons as a mechanism controlling feeding behavior and nutrient partitioning through distinct kinase activation and lipophagic processes.

This study shows that bone-derived hormone osteocalcin regulates locomotion by maintaining mitochondrial function in spinal motoneurons, and that this effect can be reversed in aged mice.

This study investigates how food restriction in a mouse model of anorexia nervosa affects gut microbiota and intestinal gluconeogenesis, revealing their roles in maintaining glucose homeostasis.

Skeletal muscle from individuals at elevated genetic risk for ALS/FTD undergoes progressive metabolic reprogramming far before disease onset.

This paper introduces a computational framework to identify genetic mouse models for rare obesity, revealing links between obesity and 16 other diseases.

The paper identifies long-range GABAergic inhibitory feedback from cortical areas to the olfactory bulb, showing its role in modulating sensory processing and odor discrimination.

The paper investigates SARS-CoV-2 viroporins Orf3a and E protein using multi-omics approaches to understand their role in ion homeostasis and inflammatory responses during infection.

This study shows that age-related gut microbiota impair hippocampus-dependent memory via a vagus nerve-dependent mechanism, and suggests pharmacogenetic vagus stimulation as a potential therapeutic strategy.

The paper shows that odor experience correlates individual GC activity with spine stability, driven by MC activity, and models how this supports odor discrimination and memory.

The paper models the structure of SARS-CoV-2 E-protein, identifying potential proton channeling activity and suggesting it as a target for antiviral strategies.

The paper shows that stress alters gut microbiota, which can induce depression and reduce neurogenesis, but this effect is blocked by vagus nerve disruption.