Inhibition of cortico-amygdala projections underlies affective bias modification by psilocybin
Matthew D. B. Claydon, Justyna K. Hinchcliffe, Julia M. Bartlett, Caroline T. Golden, Christopher Webb Thomas, Gary Gilmour, Jack R. Mellor, Bortolotto Za, Emma S J Robinson
This study identifies modulation of the prelimbic cortico-amygdala circuit by psilocin as key to affective bias modification and antidepressant effects in a rodent model.
bioRxiv · Mar 4, 2026 · PreprintNeuroscience