Emma S. J. Robinson

The paper investigates strain differences in extrinsic and intrinsic motivation tasks in mice, finding divergent motivational phenotypes across strains.

This study examines the acute and post-acute effects of psilocybin and LSD on cognitive flexibility in rats using two probabilistic reversal learning tasks, finding no robust enhancement of reversal learning.

This study modifies the 3-chamber test to better assess affiliative social motivation in mice by incorporating direct interaction and social status, revealing sex differences and challenges to assumptions about sociability.

This study investigates how different serotonergic psychedelics and MDMA affect affective biases in male rats, finding varied impacts on memory and new experiences that may relate to their antidepressant potential.

This study tests masking agents to improve the reliability of voluntary oral dosing in rats and mice by reducing aversion to bitter-tasting compounds.

This study identifies modulation of the prelimbic cortico-amygdala circuit by psilocin as key to affective bias modification and antidepressant effects in a rodent model.

Psilocybin reverses reward learning deficits in a rat model of depression within 24 hours, with effects lasting at least 7 days.

This study examines dose selection in animal models of antidepressants and finds that conventional models often use doses higher than clinical equivalents, potentially leading to irrelevant mechanisms being studied.

This study compares the effects of antidepressants on conditioned and innate motivation in mice, finding divergent impacts on reward-seeking behaviors.

Reward learning bias, sucrose preference, and ultrasonic vocalisation assays show that singly housed male C57BL/6 mice in conventional cages exhibit a more positive affective state than group-housed mice.

This study investigates how different NMDA antagonists modulate negative affective biases in rats, finding that some induce sustained positive biases linked to antidepressant effects.

This study examines the effects of early life stress on hippocampal NMDAR function in rats, finding altered AMPA/NMDA ratios without changes in LTP.

This study investigates whether aged rats exhibit behavioural deficits relevant to apathy syndrome across multiple domains, finding deficits in cognitive flexibility but not other domains, suggesting aged rats are not a suitable model for age-related apathy.

This study shows that reduced DLG2 expression in rats impairs hippocampal synaptic integration and plasticity, which can be reversed by muscarinic M1 receptor agonists.

This study characterizes the Dlg2 haploinsufficiency rat model, finding reduced PSD-93 expression and specific behavioral changes linked to psychosis vulnerability without other deficits.

The paper investigates how prefrontal cortex and hippocampus interact during working memory tasks in rats, showing that mPFC leads in maintaining sample information and that rhythmic assembly dynamics are critical for task performance.

This study tests how acute and chronic pro-depressant and immunomodulatory drugs affect decision-making bias in rats using a judgement bias task, finding chronic treatments induce negative biases while acute ones do not.

This study investigates how rapid acting antidepressants like ketamine affect decision-making biases in rodents, identifying the medial prefrontal cortex as a key region involved.