Justyna K. Hinchcliffe

This study investigates how different serotonergic psychedelics and MDMA affect affective biases in male rats, finding varied impacts on memory and new experiences that may relate to their antidepressant potential.

This study identifies modulation of the prelimbic cortico-amygdala circuit by psilocin as key to affective bias modification and antidepressant effects in a rodent model.

Psilocybin reverses reward learning deficits in a rat model of depression within 24 hours, with effects lasting at least 7 days.

This study examines dose selection in animal models of antidepressants and finds that conventional models often use doses higher than clinical equivalents, potentially leading to irrelevant mechanisms being studied.

Reward learning bias, sucrose preference, and ultrasonic vocalisation assays show that singly housed male C57BL/6 mice in conventional cages exhibit a more positive affective state than group-housed mice.

This study investigates how different NMDA antagonists modulate negative affective biases in rats, finding that some induce sustained positive biases linked to antidepressant effects.