Multivalent Tri-Functional T-cell Engagers by Chemically Induced Protein Self-Assembly
Declan Dahlberg, Brandi McKnight, Abhishek Kulkarni, Lakmal Rozumalski, Freddys F. Rodriguez, Yiao Wang, Carston R. Wagner
This paper develops a modular platform for multivalent T-cell engagers using chemically self-assembled nanorings to overcome antigen escape and tumor heterogeneity in solid tumors.
bioRxiv · Jul 29, 2025 · PreprintImmunology