Author

Freddys F. Rodriguez

University of MinnesotaORCID 0000-0002-0870-2838Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:proteomics· 3 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 1 Approach:mechanistic / dynamical model· 1

Frequent Co-Authors

Abhishek Kulkarni· 3 shared Carston R. WagneriD· 3 shared Declan Dahlberg· 3 shared Lakmal Rozumalski· 3 shared Debasmita PauliD· 2 shared Brandi McKnight· 1 shared Jasmine FooiD· 1 shared Kamran KavehiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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3 shared papersImmunology

Abhishek Kulkarni

Mutual co-authors in cluster

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3 papers

Recent·Most cited

T-cell Receptor (TCR) targeting with Multivalent T-cell Engagers

Debasmita Paul, Abhishek Kulkarni, Freddys F. Rodriguez, Declan Dahlberg, Lakmal Rozumalski, Carston R. Wagner

This study designs multivalent T-cell engagers using nanobodies targeting TCR/CD3 complex to improve safety and specificity compared to traditional CD3scFv-based TCEs.

bioRxiv · Jun 15, 2026 · PreprintImmunology

Understanding heterogeneous responses to T cell engagers: Binding characteristics and dosing thresholds determine cytotoxic efficacy

T. Simmons, Abhishek Kulkarni, Debasmita Paul, Freddys F. Rodriguez, Declan Dahlberg, Lakmal Rozumalski, Kamran Kaveh, Carston R. Wagner, Kevin Leder, Jasmine Foo

The paper investigates how binding characteristics and dosing thresholds affect the efficacy of T cell engagers across different donors and constructs.

bioRxiv · Mar 25, 2026 · PreprintImmunology

Multivalent Tri-Functional T-cell Engagers by Chemically Induced Protein Self-Assembly

Declan Dahlberg, Brandi McKnight, Abhishek Kulkarni, Lakmal Rozumalski, Freddys F. Rodriguez, Yiao Wang, Carston R. Wagner

This paper develops a modular platform for multivalent T-cell engagers using chemically self-assembled nanorings to overcome antigen escape and tumor heterogeneity in solid tumors.

bioRxiv · Jul 29, 2025 · PreprintImmunology