Carston R. Wagner

This study designs multivalent T-cell engagers using nanobodies targeting TCR/CD3 complex to improve safety and specificity compared to traditional CD3scFv-based TCEs.

The paper investigates how binding characteristics and dosing thresholds affect the efficacy of T cell engagers across different donors and constructs.

This paper develops a modular platform for multivalent T-cell engagers using chemically self-assembled nanorings to overcome antigen escape and tumor heterogeneity in solid tumors.

This study develops HINT1 inhibitors to explore their effects on MOR-NMDAR cross-regulation and analgesia, showing selective modulation of pain pathways without affecting opioid tolerance.

The paper characterizes the transcriptome-wide dynamics of translation initiation stages in a higher eukaryote and identifies regulators at each step.