T-cell Receptor (TCR) targeting with Multivalent T-cell Engagers
Debasmita Paul, Abhishek Kulkarni, Freddys F. Rodriguez, Declan Dahlberg, Lakmal Rozumalski, Carston R. Wagner
This study designs multivalent T-cell engagers using nanobodies targeting TCR/CD3 complex to improve safety and specificity compared to traditional CD3scFv-based TCEs.
bioRxiv · Jun 15, 2026 · PreprintImmunology