Author

Brandon J. C. Klein

University of Michigan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:bacteria (other)· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

Frequent Co-Authors

Amanda L. GarneriD· 2 shared Chase A. WeidmanniD· 1 shared Dalia M. SoueidiD· 1 shared Emilio L. Cárdenas· 1 shared Gabriela Vega-Hernández· 1 shared Hui WangiD· 1 shared Jason C. RechiD· 1 shared Jesse Duque· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersBiochemistry

Amanda L. GarnerORCID

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2 papers

Recent·Most cited

SHAPE-based chemical probes for studying preQ1-RNA interactions in living bacteria

José A. Reyes Franceschi, Emilio L. Cárdenas, Brandon J. C. Klein, Chase A. Weidmann, Amanda L. Garner

This paper develops a chemical probing strategy using preQ1 and its riboswitch RNA to study RNA-small molecule interactions in living bacteria, mapping binding sites through mutational profiling.

ACS Chemical Biology · Oct 10, 2025Peer-reviewedBiochemistry

CRISPR RiPCA for Investigating eIF4E-m7GpppX Capped mRNA Interactions

Gabriela Vega-Hernández, Jesse Duque, Brandon J. C. Klein, Dalia M. Soueid, Jason C. Rech, Hui Wang, Wenhui Zhou, Amanda L. Garner

This paper introduces CRISPR RiPCA, a platform combining CRISPR and live-cell RNA-protein interaction assays to measure inhibitor activity against eIF4E-m7GpppX interactions relevant to cancer drug discovery.

ACS Chemical Biology · Aug 7, 2025Peer-reviewedCell Biology