Amanda L. Garner

Altered neuronal start codon stringency favors cap-independent repeat-associated non-AUG translation

The paper shows that neurons prefer cap-independent RAN translation from specific repeats, linked to altered start codon stringency and eIF1 redistribution.

SHAPE-based chemical probes for studying preQ1-RNA interactions in living bacteria

This paper develops a chemical probing strategy using preQ1 and its riboswitch RNA to study RNA-small molecule interactions in living bacteria, mapping binding sites through mutational profiling.

CRISPR RiPCA for Investigating eIF4E-m7GpppX Capped mRNA Interactions

This paper introduces CRISPR RiPCA, a platform combining CRISPR and live-cell RNA-protein interaction assays to measure inhibitor activity against eIF4E-m7GpppX interactions relevant to cancer drug discovery.

Second-Generation Cap Analogue Prodrugs for Targeting Aberrant Eukaryotic Translation Initiation Factor 4E (eIF4E) Activity in Drug-Resistant Melanoma

This study develops second-generation cap analogue inhibitors to target eIF4E-mediated cap-dependent translation in drug-resistant melanoma cells.

Adaptation of RiPCA for the Live-Cell Detection of mRNA-Protein Interactions

This paper adapts the RiPCA technology to detect and screen mRNA-protein interactions in live cells, providing a guide for developing future assays for diverse interactions.