Author

Jason C. Rech

University of MichiganORCID 0000-0002-5876-2994Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1 Approach:wet-lab / biochemical assay· 1

Frequent Co-Authors

Amanda L. GarneriD· 1 shared Arghya ChakravortyiD· 1 shared Bhaskar K. ChatterjeeiD· 1 shared Brandon J. C. Klein· 1 shared Charles L. BrooksiD· 1 shared Dalia M. SoueidiD· 1 shared Gabriela Vega-Hernández· 1 shared Hui WangiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperCell Biology

Amanda L. GarnerORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

CRISPR RiPCA for Investigating eIF4E-m7GpppX Capped mRNA Interactions

Gabriela Vega-Hernández, Jesse Duque, Brandon J. C. Klein, Dalia M. Soueid, Jason C. Rech, Hui Wang, Wenhui Zhou, Amanda L. Garner

This paper introduces CRISPR RiPCA, a platform combining CRISPR and live-cell RNA-protein interaction assays to measure inhibitor activity against eIF4E-m7GpppX interactions relevant to cancer drug discovery.

ACS Chemical Biology · Aug 7, 2025Peer-reviewedCell Biology

Small molecule FICD inhibitors suppress endogenous and pathologic FICD-mediated protein AMPylation

Bhaskar K. Chatterjee, Muhammad Mansoor Alam, Arghya Chakravorty, Shannon M. Lacy, William Giblin, Jason C. Rech, Charles L. Brooks, Peter Arvan, Matthias C. Truttmann

This study identifies two small molecule inhibitors of FICD that suppress both endogenous and pathologic protein AMPylation, improving proinsulin processing in β cells.

ACS Chemical Biology · Mar 4, 2025Peer-reviewedCell Biology