The Plasmepsin-Piperaquine Paradox Persists
Breanna Walsh, Robert L. Summers, Gabriel W. Rangel, Laura M. Hagenah, Sachel Mok, Manuel Llinás, David A. Fidock, Dyann F. Wirth, Selina E. R. Bopp
This study uses CRISPR/Cas9 to knockout plasmepsin II and III in Cambodian malaria parasites, showing increased sensitivity to piperaquine and linking plasmepsin gene copy numbers to PPQ resistance.
PLoS Pathogens · Jul 28, 2025Peer-reviewedMolecular Biology