Selina E. R. Bopp

The paper identifies new drug targets in Plasmodium falciparum using thermal proteome profiling combined with molecular docking and MS-CETSA.

The paper identifies PfApiAT2 as a proline transporter essential for Plasmodium falciparum oocyst development in mosquitoes, showing that its absence leads to defective sporozoite production and oocyst degeneration.

This study identifies PfCoronin's role in artemisinin resistance by showing mutations impair hemoglobin uptake and modulate drug susceptibility during the ring stage of Plasmodium falciparum.

This study shows that severe malarial anaemia is linked to increased red blood cell production, iron metabolism, tissue injury, and parasite biomass in bone marrow, with better resolution from bone marrow analysis than peripheral blood.

This study uses CRISPR/Cas9 to knockout plasmepsin II and III in Cambodian malaria parasites, showing increased sensitivity to piperaquine and linking plasmepsin gene copy numbers to PPQ resistance.

This study detects de novo mutations in Plasmodium falciparum to reconstruct disease transmission pathways and identify clade expansions not detectable with previous methods.

Whole genome sequencing reveals how Plasmodium falciparum evolves resistance to diverse compounds and identifies new antimalarial drug targets.