Gabriel W. Rangel

This study uses CRISPR/Cas9 to knockout plasmepsin II and III in Cambodian malaria parasites, showing increased sensitivity to piperaquine and linking plasmepsin gene copy numbers to PPQ resistance.

This study shows that disrupting the hexosamine biosynthetic pathway in Plasmodium falciparum blocks GPI production, arrests parasite growth, and prevents egress from host cells.

The paper identifies multiple redundant carboxylic acid transporters in Plasmodium falciparum that support mitochondrial metabolism, revealing metabolic flexibility in the parasite.