Sachel Mok

This study identifies a PX1 haplotype in Plasmodium falciparum associated with reduced susceptibility to artemisinin and lumefantrine, providing a marker for drug resistance surveillance.

This study identifies a novel K13 double mutation conferring resistance to ozonide antimalarials in Plasmodium falciparum parasites with existing artemisinin resistance.

This paper models recombination's impact on multi-drug resistance evolution in malaria, showing that most recombinant genotypes arise from multi-clonal infections and that ACT strategies reduce treatment failures and delay resistance.

This study uses CRISPR/Cas9 to knockout plasmepsin II and III in Cambodian malaria parasites, showing increased sensitivity to piperaquine and linking plasmepsin gene copy numbers to PPQ resistance.

This study compares gametocyte production and transmission fitness of ART-sensitive and ART-resistant P. falciparum isolates across multiple mosquito species.

This study identifies DMT1 and a chromosome 12 locus, including FtsH1, as novel contributors to Plasmodium falciparum resistance to quinine, alongside the known pfcrt gene.

The paper identifies genetic determinants of multidrug resistance in Plasmodium falciparum and their impact on parasite fitness and drug susceptibility.