LD Hub provides a centralized database and web interface for performing LD score regression on GWAS summary data to estimate SNP heritability and genetic correlations across traits.

bioRxiv · May 3, 2016Bioinformatics

Functional partitioning of local and distal gene expression regulation in multiple human tissues

Xuanyao Liu, Hilary K. Finucane, Alexander Gusev, Gaurav Bhatia, Steven Gazal, Luke O’Connor, Brendan Bulik-Sullivan, Fred A. Wright, Patrick F. Sullivan, Benjamin M. Neale, Alkes L. Price

This study partitions the heritability of local and distal gene expression regulation across 15 human tissues, identifying enriched functional categories and tissue-specific patterns.

bioRxiv · Mar 31, 2016 · PreprintGenomics

Genome-wide analysis of over 106,000 individuals identifies 9 neuroticism-associated loci

Daniel J Smith, Valentina Escott-Price, Gail Davies, Mark ES Bailey, Lucia Colodro Conde, Joey Ward, Alexey Vedernikov, Riccardo Marioni, Breda Cullen, Donald Lyall, Saskia P Hagenaars, David CM Liewald, Michelle Luciano, Catharine R Gale, Stuart J Ritchie, , Michael O'Donovan

This study identifies 9 new genetic loci associated with neuroticism using genome-wide data from over 106,000 individuals.

bioRxiv · Jan 23, 2016Genetics

Genetic risk for autism spectrum disorders and neuropsychiatric variation in the general population

Elise B Robinson, Beate St Pourcain, Verneri Anttila, Jack Kosmicki, Brendan Bulik-Sullivan, Jakob Grove, Julian Maller, Kaitlin E Samocha, Stephan Sanders, Stephan Ripke, Joanna Martin, Mads V Hollegaard, Thomas Werge, David M Hougaard, Benjamin M Neale, , Mark J Daly

The paper identifies genetic links between autism spectrum disorders and typical variation in social behavior and adaptive functioning in the general population.

bioRxiv · Sep 29, 2015Genetics

An Atlas of Genetic Correlations across Human Diseases and Traits

Brendan Bulik-Sullivan, Hilary K Finucane, Verneri Anttila, Alexander Gusev, Felix R Day, ReproGen Consortium, Psychiatric Genomics Consortium, Anorexia Nervosa Genetic Consortium Wellcome Trust Consortium 3, Laramie Duncan, John R.B. Perry, Nick Patterson, Elise Robinson, Mark J Daly, Alkes L Price, Benjamin M Neale

The paper estimates genetic correlations between 25 traits using GWAS summary statistics, identifying correlations like anorexia nervosa with schizophrenia and educational attainment with diseases.

Nature Genetics · Sep 28, 2015Peer-reviewedGenomics

Mixed Models for Meta-Analysis and Sequencing

Brendan Bulik-Sullivan

The paper introduces a mixed model method for meta-analysis that nearly matches the power of pooled studies without sharing individual-level data, with potential gains in effective sample size for height and BMI studies.

bioRxiv · May 29, 2015 · PreprintGenomics

Relationship between LD Score and Haseman-Elston Regression

Brendan Bulik-Sullivan

This paper shows that LD Score regression with constrained intercept is equivalent to Haseman-Elston regression for estimating SNP-heritability in unrelated samples.

bioRxiv · Apr 20, 2015 · PreprintGenetics

Partitioning heritability by functional category using GWAS summary statistics

Hilary Kiyo Finucane, Brendan Bulik-Sullivan, Alexander Gusev, Gosia Trynka, Yakir Reshef, Po-Ru Loh, Verneri Anttilla, Han Xu, Chongzhi Zang, Kyle Farh, Stephan Ripke, Felix Day, ReproGen Consortium, Schizophrenia Working Group of the Psychiatric Genetics Consortium, RACI Consortium, , Alkes L. Price

This paper partitions heritability across functional genomic elements using GWAS summary statistics to identify trait-specific enrichments.

bioRxiv · Jan 23, 2015Genetics