Philip Haycock

This paper identifies shared genetic loci between inflammation and cancer risk using non-causal associations, revealing potential therapeutic targets.

This study identifies somatic mutations and mutational signatures associated with cancer-associated venous thromboembolism in a large cohort.

This paper uses Mendelian randomization and electronic health records to show SGLT2 inhibitors reduce prostate cancer risk, with additional evidence from differential expression analysis.

This study investigates the relationship between genetically predicted leukocyte telomere length and lung cancer risk, finding a causal association and novel susceptibility loci.

This study combines protein and gene expression QTLs to evaluate their concordance in drug target validation, finding that 25-30% of QTL pairs show discordant effects.

This paper uses Mendelian randomization and colocalization to identify causal relationships between plasma proteins and disease phenotypes, finding 111 putatively causal effects.

OpenGWAS serves 14582 harmonised, complete GWAS summary datasets (125.8 billion associations) via API, R/Python clients and GWAS-VCF downloads, with glue code for Mendelian randomization, colocalisation and fine-mapping.

This paper uses Mendelian randomisation to investigate the causal relationship between genetically predicted serum folate levels and cancer risk, finding little evidence of a causal association.

The paper identifies genetic links between impaired pulmonary function and increased lung cancer risk, showing causal relationships through Mendelian randomization and highlighting immune-related pathways.

MR-TRYX identifies novel causal pathways by leveraging horizontal pleiotropy in Mendelian randomization analyses using GWAS summary data.

PhenoSpD estimates phenotypic correlations and corrects multiple testing using GWAS summary statistics, reducing dimensionality for complex traits.

This study uses Mendelian randomization to identify genetic loci that may influence disease through DNA methylation changes, finding 1,191 effects across 62 traits with high replication in UK Biobank.

LD Hub provides a centralized database and web interface for performing LD score regression on GWAS summary data to estimate SNP heritability and genetic correlations across traits.