Author

Charles Laurin

University of BristolORCID 0000-0003-2439-9004Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 3 Bioinformatics· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 5 Assay:GWAS summary statistics· 3 Organism:human· 3 Research Focus:gene regulatory network inference· 2 Research Focus:GWAS / association mapping· 2 Research Focus:benchmarking· 1 Research Focus:database / resource· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Gibran HemaniiD· 4 shared George Davey SmithiD· 3 shared Benjamin ElsworthiD· 2 shared Caroline Laura ReltoniD· 2 shared David M. EvansiD· 2 shared Gabriel Cuéllar-PartidaiD· 2 shared Jie ZhengiD· 2 shared Lavinia PaternosteriD· 2 shared

Activity by Year

2016-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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4 shared papersGenetics

Gibran HemaniORCID

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5 papers

Recent·Most cited

GeneticsNature GeneticsPeer-reviewedSep 7, 2020

Phenome-wide Mendelian randomization mapping the influence of the plasma proteome on complex diseases

Jie Zheng, Valeriia Haberland, Denis A. Baird…·Tom R. Gaunt

This paper uses Mendelian randomization and colocalization to identify causal relationships between plasma proteins and disease phenotypes, finding 111 putatively causal effects.

811 citationstop 1%

humanproteomics

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GeneticsNature GeneticsPeer-reviewedMay 1, 2019

Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors

Nicole M. Warrington, Robin N. Beaumont, Momoko Horikoshi…·Cæcilie Trier

This study identifies genetic effects on birth weight and their impact on cardio-metabolic traits, distinguishing fetal and maternal contributions.

596 citationstop 1%

humanGWAS summary statistics

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GeneticsBehavior GeneticsPeer-reviewedNov 2, 2017

Partitioning Phenotypic Variance Due To Parent-Of-Origin Effects Using Genomic Relatedness Matrices

Charles Laurin, Gabriel Cuéllar-Partida, Gibran Hemani…·David M. Evans

The paper develops a method to partition phenotypic variance attributable to parent-of-origin effects using genomic relatedness matrices.

7 citations

statistical modelvariant effect prediction

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GenomicsbioRxivPreprintJul 10, 2017

Imprinted loci may be more widespread in humans than previously appreciated and enable limited assignment of parental allelic transmissions in unrelated individuals

Gabriel Cuéllar-Partida, Charles Laurin, Susan M. Ring…·David M. Evans

The paper identifies 35 novel and 50 known imprinted loci using DNA methylation and GWAS data, showing parent-of-origin effects that enable parental allelic transmission modeling in unrelated individuals.

5 citations

humanDNA methylation

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BioinformaticsBioinformaticsPeer-reviewedSep 22, 2016

LD Hub: a centralized database and web interface to perform LD score regression that maximizes the potential of summary level GWAS data for SNP heritability and genetic correlation analysis

JIE ZHENG, Mesut Erzurumluoglu, Benjamin Elsworth…·Benjamin Neale

LD Hub provides a centralized database and web interface for performing LD score regression on GWAS summary data to estimate SNP heritability and genetic correlations across traits.

DOI 10.1093/bioinformatics/btw613

GWAS summary statisticsstatistical model

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