Computational design of potent, broadly neutralizing anti-Nipah virus and Hendra virus miniproteins
Jeremiah Nelson Sims, Risako Gen, Kaitlin R. Sprouse, Young‐Jun Park, Zhaoqian Wang, Moushimi Amaya, Alka Jays, Brendan Larsen, Cameron Stewart, Jack T Brown, Robert J. Ragotte, Rashmi Ravichandran, Garrett Ruth, Xinting Li, Dionne K. Vafeados, , David A. Baker
This paper computationally designs thermostable miniproteins that neutralize Nipah and Hendra viruses with subnanomolar affinity and potent in vitro antiviral activity.
bioRxiv · Sep 17, 2026 · PreprintBioengineering