Risako Gen

This study identifies the endothelial protein C receptor (EPCR) as the entry receptor for Langya virus and reveals the molecular basis of its interaction with the viral attachment glycoprotein.

This paper computationally designs thermostable miniproteins that neutralize Nipah and Hendra viruses with subnanomolar affinity and potent in vitro antiviral activity.

This paper identifies a monoclonal antibody, PVA269, that broadly neutralizes multiple parainfluenza viruses by targeting the HN glycoprotein, showing potent prophylactic activity in a cotton rat model.

This study measures the functional and antigenic effects of ~8,500 F protein mutations in Nipah virus using pseudoviruses, revealing constraints on its structure and neutralization by antibodies.

This study shows SARS-CoV-2 nsp1 inhibits translation in bat cells and human cells, revealing its broad activity across mammals.

The paper shows that HKU25 clade MERS-related coronaviruses use ACE2 as a receptor, challenging prior beliefs that DPP4 was their main receptor.

HKU5 merbecoviruses use bat Pipistrellus abramus ACE2 and several artiodactyl ACE2s through a cryo-EM-defined binding mode distinct from other ACE2-using coronaviruses, showing independent evolution of ACE2 usage.