Rashmi Ravichandran

Computational design of potent, broadly neutralizing anti-Nipah virus and Hendra virus miniproteins

This paper computationally designs thermostable miniproteins that neutralize Nipah and Hendra viruses with subnanomolar affinity and potent in vitro antiviral activity.

Scalable Production of a De Novo SARS-CoV-2 Antiviral miniprotein in Escherichia coli

This paper describes the scalable production of a de novo SARS-CoV-2 antiviral miniprotein in E. coli, achieving high purity and yield for preclinical and clinical use.

Improving the immunogenicity of E. coli FimH via multivalent display on I53-50 nanoparticles

This paper improves the immunogenicity of E. coli FimH by displaying it on I53-50 nanoparticles, achieving comparable antibody responses to higher doses of monomeric FimH with reduced adjuvant needs.

Sustained Delivery of a SARS-CoV-2 Subunit Vaccine in An Adjuvanted Hydrogel Depot Enhances Vaccine Responses in Nonhuman Primates

This study shows that sustained delivery of a SARS-CoV-2 subunit vaccine in an adjuvanted hydrogel depot improves antibody responses in nonhuman primates compared to bolus vaccination.

Mannosylated nanoparticle immunogens enhance the circumsporozoite protein-specific B cell response and improve protection against sporozoite challenge

This study shows that nanoparticle vaccines with oligomannose glycans boost B cell responses and protection against malaria sporozoites compared to other glycan types.

Integrin-independent Tie2 activation using de novo designed proteins

This paper designs a de novo Tie2 binder that activates the Angiopoietin-Tie2 pathway without integrin engagement, showing improved therapeutic potential in a mouse model of ARDS.

A pan-variant miniprotein inhibitor protects against SARS-CoV-2 variants

This paper describes a miniprotein inhibitor that neutralizes multiple SARS-CoV-2 variants and protects mice against them when administered post-exposure.

De novo design of protein nanoparticles with integrated functional motifs

This paper designs de novo protein nanoparticles with integrated functional motifs, demonstrating their ability to form structured assemblies and elicit immune responses in mice.

Phylogeny-driven design of broadly protective sarbecovirus receptor-binding domain nanoparticle vaccines

This paper designs multivalent RBD nanoparticle vaccines that overcome immune imprinting and provide broad protection against SARS-CoV-2 variants and sarbecoviruses.

Solubilization of Membrane Proteins using designed protein WRAPS

This paper introduces WRAPs, designed proteins that solubilize membrane proteins without detergents, enabling structural studies and vaccine development.

A Multivalent Pan-Ebolavirus Nanoparticle Vaccine Provides Protection in Rodents from Lethal Infection by Adapted Zaire and Sudan Viruses

This study develops a multivalent nanoparticle vaccine against EBOV and SUDV, showing protection in rodents from lethal infection.

Protein nanoparticle vaccines induce potent neutralizing antibody responses against MERS-CoV

This study develops MERS-CoV vaccines using a protein nanoparticle platform, showing they induce strong neutralizing antibodies and protect mice against MERS-CoV challenge.

Detection of antibodies neutralizing historical and emerging SARS-CoV-2 strains using a thermodynamically coupled de novo biosensor system

The paper introduces a thermodynamically coupled biosensor to rapidly detect neutralizing antibodies against SARS-CoV-2 strains in serum samples.

Multivalent designed proteins protect against SARS-CoV-2 variants of concern

The paper designs and characterizes trivalent miniprotein binders that neutralize SARS-CoV-2 variants with low pM IC50 values and provide prophylactic and therapeutic protection in mice.