Chronic Sleep Disruption Activates the Transcriptional Unfolded Protein Response and Induces Compartment-Specific Proteomic Changes in Mice
Claudia Espinosa-Garcia, Dilpreet Kour, Upasna Srivastava, Sneha Malepati, Prateek Kumar, Samira Parhizkar, Brendan Tobin, Wooyoung Eric Jang, Rashmi Kumari, Britney Campbell, Jacob Stagray, Maria Henley, Xinran Liu, Levi B Wood, Victor Faundez, Srikant Rangaraju
This study shows chronic sleep disruption causes distinct transcriptional and proteomic changes in brain compartments, particularly affecting synaptic function and potentially contributing to Alzheimer's risk.
bioRxiv · Nov 4, 2026 · PreprintNeuroscience