Xinran Liu

Chronic Sleep Disruption Activates the Transcriptional Unfolded Protein Response and Induces Compartment-Specific Proteomic Changes in Mice

This study shows chronic sleep disruption causes distinct transcriptional and proteomic changes in brain compartments, particularly affecting synaptic function and potentially contributing to Alzheimer's risk.

Crystalline silica exposure causes latent biomechanical abnormalities along the cardiopulmonary axis

This study shows that a single crystalline silica exposure causes subclinical cardiopulmonary abnormalities in mice, with sex-dependent effects on lung mechanics and transcriptomic responses.

Sobetirome, a thyroid hormone receptor beta agonist, is a potential therapeutic agent for pulmonary fibrosis

This study shows that sobetirome, a thyroid hormone receptor beta agonist, reduces pulmonary fibrosis in mice and human tissue by restoring mitochondrial function and modulating apoptosis.

Three-dimensional quantitative characterization of Coxiella burnetii infection using focused ion beam-scanning electron microscopy

This paper uses FIB-SEM and machine learning to study Coxiella burnetii infection, revealing 3D structure variations in bacteria and CCVs and showing that a mutant's vacuole defect does not affect its developmental cycle.

TRU-PE: A Universal, Trackable Prime Editor Toolkit for Robust Single- and Multi-Locus Genome Engineering

TRU-PE improves prime editing efficiency and scalability for genome engineering in human cells, enabling multi-locus edits and a platform for studying genetic disorders.

All-optical visualization of specific molecules in the ultrastructural context of brain tissue

This paper introduces pan-ExM-t, an all-optical method for visualizing specific proteins in the ultrastructural context of brain tissue, demonstrating its application on various markers in mouse brain sections and neuron cultures.

Mechanism of forced-copy-choice RNA recombination by enteroviral RNA-dependent RNA polymerases

This paper investigates how enteroviral RNA-dependent RNA polymerases perform forced-copy-choice RNA recombination, showing the role of a plus-one intermediate and preference for CMP over other nucleotides.

Compartment-Specific Neurexin Nanodomains Orchestrate Tripartite Synapse Assembly

This study shows that neurexin-1 in astrocytes and neurons forms distinct nanodomains at synapses, enabling compartment-specific signaling that differentially regulates synapse function.