Dilpreet Kour

This study shows chronic sleep disruption causes distinct transcriptional and proteomic changes in brain compartments, particularly affecting synaptic function and potentially contributing to Alzheimer's risk.

This study shows that pathogenic tau in the locus coeruleus causes hyperactivity and neuropsychiatric symptoms similar to early Alzheimer's disease in mice.

This paper introduces SPARO, a method to simultaneously profile transcriptomes and proteomes of neural cell types, revealing mRNA-protein discordance patterns in astrocytes and neurons.

This study identifies synaptic proteome changes in response to neuroinflammation, revealing mitochondrial and MAPK signaling disruptions in excitatory neurons linked to Alzheimer's disease.

The paper optimizes a proximity labeling proteomics pipeline to enhance proteome coverage in neuronal and glial cells, revealing deeper insights into their biological functions and disease relevance.

This study shows that Kv1.3 inhibitors reduce neuropathology in a mouse AD model by modulating neuroinflammation, resilience, and neurovascular pathways through distinct cellular mechanisms.

The paper identifies novel Kv1.3 channel-interacting proteins in T-cells using proximity labeling, revealing interactions with immune signaling and trafficking machinery, and links some interactors to autoimmunity risk.

This study shows that BDMC improves AD pathology by enhancing autophagy, reducing senescence, and lowering amyloid beta in both astrocytes and a mouse model.