Prateek Kumar

Network analysis of mouse brain proteomes resolves molecular and cellular endophenotypes of aging and Aβ pathology

This study uses proteomics to identify aging and Aβ-related molecular changes in mouse brains and finds they are conserved in human AD proteomes.

Chronic Sleep Disruption Activates the Transcriptional Unfolded Protein Response and Induces Compartment-Specific Proteomic Changes in Mice

This study shows chronic sleep disruption causes distinct transcriptional and proteomic changes in brain compartments, particularly affecting synaptic function and potentially contributing to Alzheimer's risk.

Simultaneous profiling of native-state proteomes and transcriptomes of neural cell types using proximity labeling

This paper introduces SPARO, a method to simultaneously profile transcriptomes and proteomes of neural cell types, revealing mRNA-protein discordance patterns in astrocytes and neurons.

Neuroinflammatory Stress Preferentially Impacts Synaptic MAPK Signaling and Mitochondria in Excitatory Neurons

This study identifies synaptic proteome changes in response to neuroinflammation, revealing mitochondrial and MAPK signaling disruptions in excitatory neurons linked to Alzheimer's disease.

Deeper neuronal and glial proteomic insights using an optimized pipeline for proximity labeling proteomics

The paper optimizes a proximity labeling proteomics pipeline to enhance proteome coverage in neuronal and glial cells, revealing deeper insights into their biological functions and disease relevance.

Kv1.3 inhibition alleviates neuropathology via neuroinflammatory and resilience pathways in a mouse model of Aβ pathology

This study shows that Kv1.3 inhibitors reduce neuropathology in a mouse AD model by modulating neuroinflammation, resilience, and neurovascular pathways through distinct cellular mechanisms.

Identification of novel Kv1.3 channel-interacting proteins using proximity labelling in T-cells

The paper identifies novel Kv1.3 channel-interacting proteins in T-cells using proximity labeling, revealing interactions with immune signaling and trafficking machinery, and links some interactors to autoimmunity risk.

Entorhinal cortex vulnerability to human APP expression promotes hyperexcitability and tau pathology

This study identifies entorhinal cortex PV interneuron vulnerability to hAPP as a driver of hyperexcitability and tau pathology in Alzheimer's Disease.

Proximity labeling proteomics reveals Kv1.3 potassium channel immune interactors in microglia.

The paper identifies Kv1.3 potassium channel interactors in microglia using proximity labeling proteomics, revealing domain-specific interactions with immune signaling proteins during inflammation.

Identification of state-specific proteomic and transcriptomic signatures of microglia-derived extracellular vesicles

The paper identifies state-specific proteomic and transcriptomic signatures of microglia-derived extracellular vesicles using proteomic and transcriptomic analyses.

Native-state proteomics of Parvalbumin interneurons identifies novel molecular signatures and metabolic vulnerabilities to early Alzheimer's disease pathology

Cellular proteomic profiling using proximity labelling by TurboID-NES in microglial and neuronal cell lines.

The paper uses TurboID-NES to profile proteomes of microglial and neuronal cell lines, showing it captures a significant portion of the proteome and responds to LPS treatment.

Convergent Cerebrospinal Fluid Proteomes and Metabolic Ontologies in Humans and Animal Models of Rett Syndrome

The paper identifies shared proteomic and metabolic ontologies in Rett syndrome across species and validates them as potential biomarkers.

Cell type-specific biotin labeling in vivo resolves regional neuronal proteomic differences in mouse brain