Release of endogenous dynorphin opioids in the prefrontal cortex disrupts cognition
Antony D. Abraham, Sanne M. Casello, Selena S. Schattauer, Brenden A. Wong, Grace Or Mizuno, Karan Mahe, Lin Tian, Benjamin Bruce Land, Charles Chavkin
This study shows that dynorphin release in the prefrontal cortex during opioid withdrawal disrupts cognition, and KOR antagonism can block these effects.
Neuropsychopharmacology · Sep 20, 2021Peer-reviewedNeuroscience