Benjamin Bruce Land

This study shows CBD has both anti- and pro-nociceptive effects in larval zebrafish, with Trpa1b mediating the pro-nociceptive effects while CB1/CB2 and Trpv1 may mediate analgesia.

The paper investigates how THC impairs mouse behavior by altering mPFC excitatory/inhibitory balance through endocannabinoid release.

This study identifies nalfurafine and nalmefene as agents that cause long-lasting KOR inactivation, potentially offering new therapeutic approaches for stress-related disorders.

This study investigates the role of endocannabinoids in reward-seeking behavior through thalamo-striatal circuits using in vivo and machine learning methods.

This study identifies an insular-claustral opioid circuit that stress modulates to influence hedonic feeding through KOR signaling and prodynorphin-expressing neurons.

The paper investigates how stress affects serotonin signaling in the nucleus accumbens through dynorphin and KOR pathways, influencing cocaine preference and aversion.

This study shows that dynorphin release in the prefrontal cortex during opioid withdrawal disrupts cognition, and KOR antagonism can block these effects.