Author

Karan Mahe

California Institute of Technology

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Antony D. AbrahamiD· 1 shared Benjamin Bruce LandiD· 1 shared Bo GuiD· 1 shared Brenden A. Wong· 1 shared Charles ChavkiniD· 1 shared Dongyang LiiD· 1 shared Grace Or MizunoiD· 1 shared Lin TianiD· 1 shared

Activity by Year

2021-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperNeuroscience

Antony D. AbrahamORCID

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2 papers

Recent·Most cited

miRNA modules for precise, tunable control of gene expression

Rongrong Du, Michael J. Flynn, Karan Mahe, Monique Honsa, Bo Gu, Dongyang Li, Sean E. McGeary, Viviana Gradinaru, Ralf Jungmann, Michael B. Elowitz

The paper introduces DIMMERs, miRNA-based circuits that enable precise, tunable control of transgene expression across cell types, improving gene therapy and research applications.

Molecular Cell · Dec 19, 2025Peer-reviewedSynthetic Biology

Release of endogenous dynorphin opioids in the prefrontal cortex disrupts cognition

Antony D. Abraham, Sanne M. Casello, Selena S. Schattauer, Brenden A. Wong, Grace Or Mizuno, Karan Mahe, Lin Tian, Benjamin Bruce Land, Charles Chavkin

This study shows that dynorphin release in the prefrontal cortex during opioid withdrawal disrupts cognition, and KOR antagonism can block these effects.

Neuropsychopharmacology · Sep 20, 2021Peer-reviewedNeuroscience